Thats what I do. I have 1 drive for my OS and Programs such as excel.
I have a second hard drive for games.
In the future, I will be running 3 hard drives... 1 for the OS and ONLY the OS, 1 for programs such as office / word / graphics programs, and then my games drive
Keeps things organized, clean, and with the right usage. My OS will be on a 10,000 RPM SATA 36 gig drive. Thats all I'll run when I build a new comp in 1 - 2 years
I like the Western Digital Raptor Hard drives. 36 gig for the os, 74 gig (or if they have larger ones by then) for my programs / games drives.
BV :hat